How does the novel coronavirus (SARS-CoV-2) change its genetic material? What other infections do patients suffer from? Are there genetic predispositions to the coronavirus disease 2019 (COVID-19)? A number of genomics researchers are working hard to bring together their expertise and sequencing infrastructure to help manage the COVID-19 pandemic. In order to accelerate research, these activities are now officially combined in the German COVID-19 OMICS Initiative (DeCOI). Scientists from more than 22 institutes are already involved in DeCOI. The NFDI4Microbiota consortium and its members are actively contributing to this initiative.